Luis M. Alvarez, Principal Investigator
Ph.D. Biological Engineering, Massachusetts Institute of Technology
S.M. Chemical Engineering, Massachusetts Institute of Technology
B.S. Chemistry, United States Military Academy, West Point, NY
Luis founded the Regenerative Biology at the National Cancer Institute in 2012. His group focuses on the development of tissue engineering methods to address loss of function resulting from traumatic injury and diseases such as cancer. His research interests are motivated in part by his military experience and a desire to use new findings in regenerative medicine for the benefit of injured Service Members.
Luis was also an active duty Army officer and served within the US Army Medical Research and Materiel Command. His previous assignments include the 2nd Infantry Division (South Korea), the 1st Cavalry Division (Ft. Hood, TX and Baghdad, Iraq), and the Natick Soldier Research, Development, and Engineering Center (Natick, MA).
Awards & Fellowships:
Congressionally Directed Medical Research Program Career Development Award (2011) Hertz Foundation Fellow (1997-99, 2006-09)
Spiral-shaped inertial stem cell device for high-throughput enrichment of iPSC-derived neural stem cells. Microfluid. Nanofluidics 21, 64 (2017).
Identification of Mesenchymal Stem Cell Differentiation State Using Dual-micropore Microfluidic Impedance Flow Cytometry. Analytical Methods. Royal Society of Chemistry (2016).
Tethering of epidermal growth factor (EGF) to beta tricalcium phosphate (βTCP) via fusion to a high affinity, multimeric βTCP-binding peptide: effects on human multipotent stromal cells. PLOS One. (2015)
Continuous-flow sorting of stem cells and differentiation products based on dielectrophoresis. Lab on a Chip (2015).
An Engineered Bivalent Neuregulin Protects Against DoxorubicinInduced Cardiotoxicity with Reduced ProNeoplastic Potential. Circulation (2013).
Multilayer Thinfilm Coatings Capable of Extended Programmable Drug Release: Application to Human Mesenchymal Stem Cell Differentiation. Drug Delivery and Translational Research (2012), 2, 375–383.
Engineered Bivalent Ligands to Bias ErbB Receptormediated Signaling and Phenotypes. Journal of Biological Chemistry (2011), 286, 27729–27740.
Synergistic Effects of Tethered Growth Factors and Adhesion Ligands on DNA Synthesis and Function of Primary Hepatocytes Cultured on Soft Synthetic Hydrogels. Biomaterials (2010), 31, 4657–71.
George Klarmann, Research Scientist
Post-Doctoral Fellow, HIV Drug Resistance Program, National Cancer Institute-Frederick
Ph.D. Biochemistry, University of Utah
B.S. Molecular and Cell Biology, University of Connecticut
George has extensive experience in biochemistry and cell biology. His previous work includes studying the biochemical mechanisms of HIV-1 DNA synthesis and reverse transcriptase nucleotide substrate selection as well as the link between epithelial-to-mesenchymal transition, basement membrane invasion, and cancer stem cells. In his most recent work George led a research group at a major cell biology company where he focused on product development in the areas of hematopoietic, mesenchymal and adipose-derived stem cell differentiation, and the establishment and applications of 3D air-liquid interface culture systems for primary airway epithelial cells.
Joseph Loverde, Research Scientist
Ph.D. Biomedical Engineering, New Jersey Institute of Technology & Rutgers Biomedical and Health Sciences
M.S. Bioinformatics, Northeastern University
B.S. Biology, Muhlenberg College
Joseph's background is in neurobiology and mechano-transduction of cell signaling in neurons. He heads up the group's work in nerve regeneration at the Center for Molecular Science at the United States Military Academy. His work in stretch-mediated axon growth has been featured in a Jove article describing the process of mechanically induced growth.
Averell Gnatt, Research Scientist
Postdoc Structural Biology, Stanford University
Ph.D. Biochemistry, Hebrew University of Jerusalem, Givat-Ram, Israel
M.S. Neurobiology, Weizmann Institute of Science, Rehovot, Israel
B.S. Biology, Bar-Ilan University, Ramat-Gan, Israel
Ave's has an extensive background is in structural biology with a focus on x-ray crystallography. His early work with Roger Kornberg at Stanford contributed to the eludication of key steps in RNA transcription in yeast. Ave's work set a firm foundation in this field with the 2001 publication of "Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution" in the journal Science.